Posts Tagged ‘Osteoporosis’
Primary Sclerosing Cholangitis: Complications
Cholestasis
Among the manifestations of cholestasis associated with primary sclerosing cholangitis should be mentioned:
- Itching
- Steatorrhea and fat-soluble vitamin deficiency: Decreased bile acid secretion into the intestine interferes with the absorption of fat soluble vitamins. Although frank diarrhea and steatorrhea are uncommon, deficiency of vitamin A, D, E and K are relatively common. The differential diagnosis of diarrhea are some conditions that are more common in patients with primary sclerosing cholangitis, such as chronic pancreatitis and celiac disease.
- Osteoporosis: sclerosing cholangitis, as primary biliary cirrhosis, is frequently associated with osteoporosis. The cause of osteoporosis is not completely clear, since vitamin D deficiency produces osteomalacia rather than osteoporosis. Patients with sclerosing cholangitis have an increased risk of fractures, particularly those patients who have undergone liver transplantation. Read the rest of this entry »
Bone diseases
By their nature, bone, and connective tissue support rigid and soft tissues of the body, is subject to risk factors that may condition its stability and functional capacity.
1. The origin of the pathologies
There are metabolic disorders which affect bone health throughout our lives, most of which are caused by the increased number and activity of osteoclasts (bone tissue removed), which exceeds the capacity to compensate for the osteoblasts (bone forming cells).
Shares of many of the diseases that affect adults, such as osteoporosis and rheumatoid arthritis, are either a result of abnormal metabolism and bone remodeling, or the result of a chronic inflammatory process affecting the structure and function of bone.
Recent studies suggest that the onset and severity of these pathologies may be delayed or lessened if bone modeling is optimized during the early phases of life or if diets are supplemented adequately with certain nutrients that reduce the concentration of factors that alter skeletal health .
2. Osteoporosis
Osteoporosis is most common bone disease, manifested in 40% of Spanish women and 11% of men over 70 years. It is characterized by loss of bone mass, microarchitectural deterioration of bone tissue and increased fracture risk.
The relative impact of environmental and genetic factors in osteoporosis is not well defined: Epidemiological studies suggest that environmental factor is the most decisive, while studies on bone mass among brothers (twins) validate the role of genetic factors . With the rapid advancement of the Human Genome Project and biotechnology, will be possible to evaluate new genes involved in osteoporosis and fracture risk calculated for each individual in the context of environmental influences.